Cisplatin zebrafish
WebFeb 8, 2024 · Adult zebrafish injected with cisplatin shows decreased survival, kidney cell death, and increased inflammation markers after 24 h post-injection (hpi). In this model, … WebFeb 15, 2024 · The cisplatin was used to produce a loss of CHCs to create a murine model of deafness. The AAV vectors were delivered into the scala media through the lateral wall. Compared with the control mice, the cisplatin-treated mice exhibited significantly enhanced apoptosis and autophagy in the cochleae, accompanied by a notably decreased Pou4f3 …
Cisplatin zebrafish
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WebCisplatin-induced hair cell loss in zebrafish (Danio rerio) lateral line We have used time-lapse imaging to study cisplatin-induced hair cell death in lateral line neuromasts of zebrafish larvae in vivo. We found that cisplatin-induced hair cell death occurred much more slowly than had been shown to occur in aminoglycoside-induced hair cell death. WebNov 18, 2024 · Cisplatin is an effective anticancer agent, but also causes permanent hearing loss by damaging hair cells-the sensory receptors essential for hearing. There is an urgent clinical need to protect cochlear hair cells in …
WebFeb 6, 2014 · Zebrafish were exposed to 1000 μM cisplatin for 6 h. We, then, periodically monitored swimming depth, total swimming distance, peak swimming velocity, and mean swimming velocity of the fish for approximately 21 days. WebJan 1, 2024 · This study provides evidence that cisplatin-induced hair cell loss in zebrafish is accompanied by protein nitration and Lmo4 degradation, which are emerging as …
WebNov 18, 2024 · Zebrafish have been used in many studies as an in vivo model to evaluate the cellular mechanisms of cisplatin-induced hair cell death and to identify potential … WebJan 1, 2024 · Exposure of zebrafish larvae (5dpf) to 1000 μM of cisplatin for 4 h induced extensive loss of hair cells in the neuromasts in the anterior, middle, and posterior regions ( Fig. 1 ). A similar loss of hair cells with a dose of cisplatin ranging from 250 to 1500 μM cisplatin was reported by Ou et al. (2007).
WebInner ear sensory hair cells die following exposure to aminoglycoside antibiotics or chemotherapeutics like cisplatin, leading to permanent auditory and/or balance deficits in humans. Zebrafish (Danio rerio) are used to study drug-induced sensory hair cell death since their hair cells are similar in structure and function to those found in humans.
WebUsing zebrafish embryos as a model, cisplatin was previously found to impair skin ionocytes and ion regulation. The purpose of this study was to further investigate how cisplatin damages ionocytes. Zebrafish embryos were exposed to cisplatin (0, 50, and 100 μM) for 96 h (4-100 h post-fertilization) and then stained with fluorescent dyes to ... the pinball zoneWebDec 1, 2024 · Cisplatin ototoxicity Zebrafish Mitochondrial dysfunction Mitochondrial bioenergetics 1. Introduction Cisplatin is a chemotherapeutic agent that is commonly used in the treatment of solid tumors. sideboard country styleWebCisplatin is a very effective anticancer drug and generates reactive oxygen species (ROS) such as superoxide anions that can deplete antioxidant protective molecules in the cochlea. ... An in vivo study of transgenic zebrafish (Brn3C: EGFP) was used to investigate the protective effects of apocynin on cisplatin-induced hair cell death. In an in ... the pinball wizard switchWebMay 1, 2024 · Cisplatin is a well-known chemotherapy medication used to treat numerous cancers. However, treatment with cisplatin in cancer therapy has major side effects, such as nephrotoxic acute kidney injury. Adult vertebrate kidneys are commonly used as models of cisplatin-induced nephrotoxic acute kidney injury. sideboard historyWebJul 3, 2024 · Cisplatin is a widely used chemotherapeutic agent with a high degree of ototoxicity and an average incidence of over 60% ( Karasawa and Steyger, 2015 ). Ototoxicity depends on several factors, including patient … sideboard for conference roomWebMar 3, 2013 · Zebrafish were pretreated with cimetidine for 1 h, followed by cotreatment with 50 μ m cisplatin for an additional 24 h. We found no significant protection against cisplatin-induced hair cell loss for all concentrations of cimetidine evaluated ( p > 0.05, one-way ANOVA; Fig. 1a ). Figure 1. sideboard eiche san remoWebNov 18, 2024 · Cisplatin is an effective anticancer agent, but also causes permanent hearing loss by damaging hair cells—the sensory receptors essential for hearing. There is an urgent clinical need to protect cochlear hair cells in … sideboard heater