Polypyrimidine tract binding protein 1
WebPlays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to … WebRNA processing is altered during malignant transformation, and expression of the polypyrimidine tract-binding protein (PTB) is often increased in cancer cells. Although …
Polypyrimidine tract binding protein 1
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WebFeb 3, 2024 · RNA binding proteins play an important role in regulating alternative pre-mRNA splicing and in turn cellular gene expression. Polypyrimidine tract binding proteins, … WebRNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of …
WebApr 22, 2015 · Abstract and Figures. Polypyrimidine tract-binding protein (PTBP1) is an RNA-binding protein with various molecular functions related to RNA metabolism and a … Webpolypyrimidine tract binding protein 1: RGD ID: 62047: Description: Enables nucleic acid binding activity and single-stranded DNA endodeoxyribonuclease activity. Involved in …
WebThe polypyrimidine tract binding (PTB) protein family of RBPs are important posttranscriptional regulators of gene expression. In the nervous system, the function and … WebThe polypyrimidine tract is a region of pre-messenger RNA (mRNA) that promotes the assembly of the spliceosome, the protein complex specialized for carrying out RNA …
WebFIGURE 1 Regulation of polypyrimidine tract-binding protein 1 (PTBP1) and pyruvate kinase M (PKM) isoforms by microRNAs: schematics. Brain and muscle-specific miRNAs bind to the 3′ UTR of PTBP1 and downregulate PTBP1 expression. PKM1 dominance is induced through the suppression of alternative splicing in these healthy organs.
WebApr 14, 2024 · Further investigation presents that ZNF649-AS1 binds to polypyrimidine tract binding protein 1 (PTBP1), which stimulates the translation of ATG5 and thus results in enhanced autophagic activity, thereby contributing to the acquisition of trastuzumab resistance . EGFR inhibitors ... song liar liar by the castawaysWebApr 13, 2024 · AC006064.4–201 directly interacts with Polypyrimidine tract-binding protein 1 (PTBP1) in HCs. A Five proteins with highest pep score of AC006064.4–201 RPD-MS and their effects on Mmp13, Aggrecan, p21 and p53 assessed by western blotting analysis. B Coomassie brilliant blue staining of proteins binding to AC006064.4–201. song licenseWebMay 30, 2000 · We have used the yeast two-hybrid system to isolate Nova interacting proteins and identify an RNA binding protein that is closely related to the polypyrimidine tract-binding protein (PTB). The expression of this protein, brPTB, is enriched in the brain, where it is expressed in glia and neurons. brPTB interacts with Nova proteins in cell lines … song licensingWebJan 15, 2003 · Two proteins, poly r(C) binding protein 1 (PCBP1) and polypyrimidine tract binding protein (PTB), were found to increase the activity of the Bag‐1 IRES in vitro and in … song life gets tedious don\u0027t itWebDec 16, 2008 · PTHR15592:SF17 POLYPYRIMIDINE TRACT-BINDING PROTEIN 3 1 hit; PROSITE. View protein in PROSITE; PS50102 RRM 4 hits; Pfam. View protein in Pfam; … song licenceWebHere we show that the RNA binding protein PTBP1 (polypyrimidine tract-binding protein) directly targets the 5′-UTR of AXL mRNA in vitro and in vivo. Moreover, we also demonstrate that PTBP1, but not PTBP2, inhibits the expression of AXL mRNA and the RNA recognition motif 1 (RRM1) of PTBP1 is crucial for this interaction. smallest dishwasher madeWebDec 27, 2024 · Polypyrimidine tract–binding protein 1 (PTBP1), an essential gene for the Warburg effect, regulates this cancer‐specific energy metabolism via alternative splicing (AS) of pyruvate kinase. 6 PTBP1 decreases the expression of the M1 isoform of pyruvate kinase (PKM1) and promotes the expression of PKM2, which leads mainly to a metabolic … smallest dishwasher