Shumiya cataract rat

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August undefined, 2024

WebThe role of proteolytic enzymes in Shumiya cataract rats in alterations to lens proteins during cataract formation was studied immunohistochemically using antibodies against exopeptidases, such as lysosomal dipeptidyl peptidase II (DPP II), cytosolic dipeptidyl peptidase III, and soluble and membrane-bound alanyl aminopeptidases, and against … WebCataract is a phenomenon in which the eye becomes opaque resulting in severe visual impairment, and senile cataract is the most common cause of blindness in the world. We …

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WebNov 28, 1997 · The Shumiya cataract rat (SCR) is a hereditary cataract model in which lens opacity appears spontaneously in the nuclear and perinuclear portions at 11–12 weeks of … WebThe Shumiya cataract rat (SCR) is a hereditary cataractous strain. It is thought that the continuous occur-rence of poorly differentiated epithelial cells at the bow area of the lens … fish scales shower curtain

Lanosterol synthase mutations cause cholesterol deficiency …

WebWe previously found that the increases in Ca 2+ content in the lenses of three hereditary cataract model rats, UPL rat (UPLR), Shumiya cataract rat (SCR) and Ihara cataract rat (ICR), are inhibited by aminoguanidine, a selective inhibitor of inducible nitric oxide synthase, and that the mechanisms of Ca 2+ enhancement in these rat models differ. In this study, we … WebWe discovered that the cataract development in the Shumiya cataract rat (SCR) can be prevented by the administration of deep-sea drinking water (DDW). A standard diet based … candlewood ridge groton ct

Shumiya cataract rat

WebAug 20, 2024 · The lens of cataract rats had α-A crystallin expression levels increased by 35% when compared to the control (Fig. 2E). ... Lanosterol synthase mutations cause cholesterol deficiency-associated cataracts in the Shumiya cataract rat. J. Clin. Invest., 116 (2006), pp. 395-404. CrossRef View Record in Scopus Google Scholar WebOct 1, 2001 · Aminoguanidine-treatment results in the inhibition of lens opacification and calpain-mediated proteolysis in Shumiya cataract rats (SCR). Inomata M, Hayashi M, Shumiya S, Kawashima S, Ito Y. J Biochem, 128(5):771-776, 01 Nov 2000 Cited by: 23 articles PMID: 11056389

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WebJun 1, 2006 · Search life-sciences literature (Over 39 million articles, preprints and more) WebThe Shumiya cataract rat (SCR) and normal control rat strains of NC1 and NC2 were established. Mean cataract appearance in adult SCR rats was 66.7%, and embryo death …

WebαB-crystallin decreased with age in lens ﬁbres of cataract rats. Calpains (µ- and m-), 20S proteasome, dipeptidyl peptidases II and III and soluble alanyl aminopeptidase are … WebMar 29, 2005 · Cataract onset is associated with the specific combination of Lss and Fdft1 mutant alleles that decrease cholesterol levels in cataractous lenses to about 57% of normal. Cholesterol insufficiency may cause the deficient proliferation of lens epithelial cells in Shumiya cataract rats, resulting in the loss of homeostatic epithelial cell control of the …

WebSix-week-old Shumiya cataract rats were used to perform experiments. The right eye of each rat was injected with TAT-HA-Prdx6 WT-NPs or TAT-HA-Prdx6 K122/142R-NPs, whereas the left eyes were administered with TAT-HA-Prdx6 Inactive-mutant-NPs. The subconjuctival injection was made using micro-syringes fitted with 30-gauge needles. WebNov 2, 2024 · The Shumiya cataract rat (SCR) is a model for hereditary cataract. Two-thirds of these rats develop lens opacity within 10-11 weeks. Onset of cataract is attributed to …

WebJul 4, 2024 · The Shumiya cataract rat (SCR) is a hereditary cataractous rat strain, which is classed as two models (non-cataract type, SCR-N, and cataractous type, SCR-C) . SCR-N (ctr1 × ctr1, Ctr2 × Ctr2), without the mutations causing premature cataracts, maintains a transparent lens, although slight lens structure collapse was observed at 8–12 weeks of …

WebJul 21, 2024 · We previously designed ophthalmic nanosuspensions of LAN (LAN-ONSs) and reported that repeated instillation of LAN-ONSs attenuated the slight collapse of the lens structure in Shumiya cataract rats (SCR), although the serious structural collapses were not reversed with the instillation of LAN-ONSs, and repeated instillation could not reverse or ... candlewood ridge hoaWebFeb 1, 2006 · The Shumiya cataract rat (SCR) and normal control rat strains of NC1 and NC2 were established. Mean cataract appearance in adult SCR rats was 66.7%, and embryo … candlewood ridgeWebPurpose: To conduct a long-term observation study of SCR rats that had developed a mature cataract at 11 weeks of age at 3-month intervals until the rats were 12 months old. Methods: Lenses of 15 rats were examined with both light and electron microscopes.. Results: At 12 weeks, opacity was observed in the perinuclear zone and the cortical intermediate layer. candlewood richmond southWebJul 10, 2003 · Methods Selenite cataract was induced in Sprague–Dawley rats by five subcutaneous injections of sodium ... activity in selenite nuclear cataract 20 and Shumiya cataract 21 in rat. ... candlewood richmond vaWebAug 4, 2024 · Six-week-old Shumiya cataract rats were used to perform experiments. The right eye of each rat was injected with TAT-HA-Prdx6 WT-NPs or TAT-HA-Prdx6 K122/142R-NPs, whereas the left eyes were administered with TAT-HA-Prdx6 Inactive-mutant-NPs. The subconjuctival injection was made using micro-syringes fitted with 30-gauge needles. candlewood ridge rentonWebcataract drug for human cataracts has not yet been intro-duced. In studies to develop anti-cataract drugs, the selection of the experimental animal is very important. The UPL rat (UPLR), Shumiya cataract rat (SCR) and Ihara cataract rat (ICR/f; ICR) are hereditary cataractous strains, and it has been shown that these rats provide useful models ... fish scale stained glass lampWebDelay of cataract development in the Shumiya cataract rat by water containing enhanced concentrations of magnesium and calcium Curr Eye Res. 2007 May;32(5):439-45. doi: … candlewood richmond